Evidence that the malignant lymphoma of Sjögren's syndrome is a monoclonal B-cell neoplasm.

  title={Evidence that the malignant lymphoma of Sj{\"o}gren's syndrome is a monoclonal B-cell neoplasm.},
  author={J I Zulman and Ronald Jaffe and Norman Talal},
  journal={The New England journal of medicine},
  volume={299 22},
We studied the malignant lymphomas that developed in patients with Sjögren's syndrome and the antecedent benign salivary-gland lesions to determine their cellular characteristics. We used an immunoperoxidase technic that identified intracellular gamma, alpha and mu heavy chains and kappa and lambda light chains. In six of nine patients, the lymphomas were composed of cells containing intracytoplasmic immunoglobulin that was exclusively IgMK. The benign lymphoepithelial salivary-gland lesions… CONTINUE READING

From This Paper

Topics from this paper.
43 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 43 extracted citations

Similar Papers

Loading similar papers…