Evidence that the localization of the elongation factor Spt16 across transcribed genes is dependent upon histone H3 integrity in Saccharomyces cerevisiae.

@article{Duina2007EvidenceTT,
  title={Evidence that the localization of the elongation factor Spt16 across transcribed genes is dependent upon histone H3 integrity in Saccharomyces cerevisiae.},
  author={Andrea A Duina and Anne Rufiange and John Bracey and Jeffrey Hall and Amine Nourani and Fred Winston},
  journal={Genetics},
  year={2007},
  volume={177 1},
  pages={101-12}
}
A previous study of histone H3 in Saccharomyces cerevisiae identified a mutant with a single amino acid change, leucine 61 to tryptophan, that confers several transcriptional defects. We now present several lines of evidence that this H3 mutant, H3-L61W, is impaired at the level of transcription elongation, likely by altered interactions with the conserved factor Spt16, a subunit of the transcription elongation complex yFACT. First, a selection for suppressors of the H3-L61W cold-sensitive… CONTINUE READING

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