Evidence that the leucine zipper is a coiled coil.

  title={Evidence that the leucine zipper is a coiled coil.},
  author={Erin K O'Shea and Ryszard Rutkowski and Peter S. Kim},
  volume={243 4890},
Recently, a hypothetical structure called a leucine zipper was proposed that defines a new class of DNA binding proteins. The common feature of these proteins is a region spanning approximately 30 amino acids that contains a periodic repeat of leucines every seven residues. A peptide corresponding to the leucine zipper region of the yeast transcriptional activator GCN4 was synthesized and characterized. This peptide associates in the micromolar concentration range to form a very stable dimer of… CONTINUE READING