Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype.

@article{Raposinho1999EvidenceTT,
  title={Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype.},
  author={Paula D. Raposinho and Pierre Broqua and Dominique D. Pierroz and Amy Hayward and Yvon Dumont and R. Quirion and Jean Louis Junien and Michel Lucien Aubert},
  journal={Endocrinology},
  year={1999},
  volume={140 9},
  pages={
          4046-55
        }
}
A number of studies have indicated that neuropeptide Y (NPY) is a central regulator of the gonadotropic axis, and the Y1 receptor was initially suggested to be implicated. As at least five different NPY receptor subtypes have now been characterized, the aim of the present study was to reinvestigate the pharmacological profile of the receptor(s) mediating the inhibitory action of NPY on LH secretion by using a panel of NPY analogs with different selectivity toward the five NPY receptor subtypes… CONTINUE READING

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