Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline

@article{Henning1971EvidenceTT,
  title={Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline},
  author={M. Henning and A. Rubenson},
  journal={Journal of Pharmacy and Pharmacology},
  year={1971},
  volume={23}
}
  • M. Henning, A. Rubenson
  • Published 1971
  • Chemistry, Medicine
  • Journal of Pharmacy and Pharmacology
  • Mean arterial blood pressure was recorded in conscious normotensive rats through indwelling arterial catheters. The effect of l‐α‐methyldopa (α‐MD) (400 mg/kg, i.p.) was studied in animals pretreated with α‐methyl‐m‐tyrosine (400 mg/kg i.p.) 27 and 15 h before α‐MD, α‐methyl‐p‐tyrosine methylester (H 44/68) (250 mg/kg, i.p.) 1 h before α‐MD, and dl‐α‐hydrazino‐α‐methyl‐β‐(3,4‐dihydroxyphenyl) propionic acid (MK 485, 100 mg/kg, i.p.) 30 min before α‐MD. This pretreatment, which resulted in a… CONTINUE READING
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