Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline.

@article{Henning1971EvidenceTT,
  title={Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline.},
  author={Matts Henning and Allan Rubenson},
  journal={The Journal of pharmacy and pharmacology},
  year={1971},
  volume={23 6},
  pages={
          407-11
        }
}
Mean arterial blood pressure was recorded in conscious normotensive rats through indwelling arterial catheters. The effect of l-α-methyldopa (α-MD) (400 mg/kg, i.p.) was studied in animals pretreated with α-methyl-m-tyrosine (400 mg/kg i.p.) 27 and 15 h before α-MD, α-methyl-p-tyrosine methylester (H 44/68) (250 mg/kg, i.p.) 1 h before α-MD, and dl-α-hydrazino-α-methyl-β-(3,4-dihydroxyphenyl) propionic acid (MK 485, 100 mg/kg, i.p.) 30 min before α-MD. This pretreatment, which resulted in a… CONTINUE READING

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