Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90.

@article{Scherrer1993EvidenceTT,
  title={Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90.},
  author={L C Scherrer and Didier Picard and Enrique Massa and Jeffrey M. Harmon and S. Stoney Simons and Keith R. Yamamoto and William A. B. Pratt},
  journal={Biochemistry},
  year={1993},
  volume={32 20},
  pages={5381-6}
}
Previously, it has been shown that the hormone binding domain of the glucocorticoid receptor acts as a transferable regulatory cassette that can confer hormonal control onto chimeric proteins [Picard, D., Salser, S. J., & Yamamoto, K. R. (1988) Cell 54, 1073-1080]. The hormone binding domain of the glucocorticoid receptor contains its site of interaction with the 90-kDa heat-shock protein, hsp90 [Dalman, F. C., Scherrer, L. C., Taylor, L. P., Akil, H., & Pratt, W. B. (1991) J. Biol. Chem. 266… CONTINUE READING
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