Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.

@article{Tatum2011EvidenceTT,
  title={Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.},
  author={Danielle Tatum and Shisheng Li},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 20},
  pages={
          17530-5
        }
}
Global genomic repair (GGR) and transcription coupled repair (TCR) are two pathways of nucleotide excision repair (NER) that differ in the damage recognition step. How NER factors, especially GGR factors, access DNA damage in the chromatin of eukaryotic cells has been poorly understood. Dot1, a histone methyltransferase required for methylation of histone H3 lysine 79 (H3K79), has been shown to confer yeast cells with resistance to DNA-damaging agents and play a role in activation of DNA damage… CONTINUE READING
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Implication of Posttranslational Histone Modifications in Nucleotide Excision Repair

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