Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor.

@article{Kazlauskas1999EvidenceTT,
  title={Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor.},
  author={Arūnas Kazlauskas and Lorenz Poellinger and Ingemar Pongratz},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 19},
  pages={
          13519-24
        }
}
The dioxin (aryl hydrocarbon) receptor is a ligand-dependent transcription factor that induces expression of a number of genes encoding drug metabolizing enzymes. In the absence of ligand the dioxin receptor is present in the cytoplasmic compartment of the cell associated with the molecular chaperone hsp90, which has been implicated in regulating the correct folding of the ligand binding domain of the receptor. In this study we have examined a potential role of the hsp90-associated p23 protein… CONTINUE READING
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