Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan.

@article{Warren2005EvidenceTT,
  title={Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan.},
  author={Hilary S. Warren and Allison L. Jones and Craig Freeman and Jayaram Bettadapura and Christopher Richard Parish},
  journal={Journal of immunology},
  year={2005},
  volume={175 1},
  pages={207-12}
}
NKp30 (NCR3, CD337) is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive, although evidence that membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. The data presented in this report show conclusively that HS glycosaminoglycans (GAG) are not… CONTINUE READING

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