Evidence that the cells responsible for marrow fibrosis in a rat model for hyperparathyroidism are preosteoblasts.

Abstract

We examined proliferation of cells associated with PTH-induced peritrabecular bone marrow fibrosis in rats as well as the fate of those cells after withdrawal of PTH. Time-course studies established that severe fibrosis was present 7 d after initiation of a continuous sc PTH infusion (40 microg/kg.d). To ascertain cell proliferation, rats were coinfused for… (More)

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