Evidence that the bifunctional redox factor / AP endonuclease Ref-1 is an anti-apoptotic protein associated with differentiation in the developing retina

@article{Chiarini2000EvidenceTT,
  title={Evidence that the bifunctional redox factor / AP endonuclease Ref-1 is an anti-apoptotic protein associated with differentiation in the developing retina},
  author={Luciana Barreto Chiarini and Fab{\'i}ola G. de Freitas and Hilda Petrs-Silva and R. F. J. van Linden},
  journal={Cell Death and Differentiation},
  year={2000},
  volume={7},
  pages={272-281}
}
Retinal cell differentiation leads to resistance to apoptosis induced by inhibition of protein synthesis, suggesting the accumulation of anti-apoptotic proteins. The redox factor/AP endonuclease Ref-1 (APE, APEX, HAP1) affects both DNA repair and the activity of various transcription factors, and controls sensitivity to genotoxic insults. We studied the expression of Ref-1 in the retina and brain of developing rats. Ref-1 immunoreactivity increased progressively within the nucleus of… CONTINUE READING