Evidence that the aversive effects of opioid antagonists and κ-agonists are centrally mediated

@article{BalsKubik2004EvidenceTT,
  title={Evidence that the aversive effects of opioid antagonists and κ-agonists are centrally mediated},
  author={Regine Bals-Kubik and A. Herz and Toni Shaun Shippenberg},
  journal={Psychopharmacology},
  year={2004},
  volume={98},
  pages={203-206}
}
The role of central versus peripheral opioid receptors in mediating the aversive effects of opioids was examined by use of an unbiased place preference conditioning procedure in rats. The non-selective opioid antagonist naloxone (NLX) produced conditioned aversions for the drug-associated place after subcutaneous (SC) as well as intracerebroventricular (ICV) administration. Place aversions were also observed in response to the ICV administration of the selective μ-antagonist CTOP. In contrast… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Pharmacologic characteristics of nor-binaltorphimine (nor-BNI), a highly selective kappa opioid receptor antagonist

  • AE Takemori, PS Portoghese
  • Proc INRC,
  • 1988
1 Excerpt

Design and synthesis of metabolically stable analogs of dynorphin-A and their analgesic characteristics

  • S Tachibana, H Oshino, +5 authors H Miyagawa
  • 1987
1 Excerpt

Similar Papers

Loading similar papers…