Evidence that the autonomic nervous system plays a major role in the L-NAME-induced hypertension in conscious rats.

@article{Cunha1993EvidenceTT,
  title={Evidence that the autonomic nervous system plays a major role in the L-NAME-induced hypertension in conscious rats.},
  author={Roberto de S{\'a} Cunha and Antonio De Melo Cabral and Elisardo Corral Vasquez},
  journal={American journal of hypertension},
  year={1993},
  volume={6 9},
  pages={806-9}
}
The present study was designed to investigate the role of the autonomic nervous system in experimental hypertension induced by chronic administration of N-nitro-L-arginine methyl ester (L-NAME) in the drinking water (1 mg/mL) over 6 days. L-NAME ingestion caused a large rise in resting mean arterial pressure (MAP) (175 +/- 5 mm Hg) and heart rate (HR) (440 +/- 17 beats per minute) compared to nontreated control rats (resting MAP: 112 +/- 2 mm Hg and HR: 345 +/- 8 beats per minute). Ganglionic… CONTINUE READING
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