Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite.

@article{Lee2001EvidenceTT,
  title={Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite.},
  author={Catherine S N Lee and Laura A Buttitta and Chia H. Fan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 20},
  pages={
          11347-52
        }
}
The dorsal-ventral polarity of the somite is controlled by antagonistic signals from the dorsal neural tube/surface ectoderm, mediated by WNTs, and from the ventral notochord, mediated by sonic hedgehog (SHH). Each factor can act over a distance greater than a somite diameter in vitro, suggesting they must limit each other's actions within their own patterning domains in vivo. We show here that the growth-arrest specific gene 1 (Gas1), which is expressed in the dorsal somite, is induced by WNTs… CONTINUE READING
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