Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore

@article{Lopez1994EvidenceTT,
  title={Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore},
  author={George A. Lopez and Yuh Nung Jan and Lily Yeh Jan},
  journal={Nature},
  year={1994},
  volume={367},
  pages={179-182}
}
POTASSIUM channels are highly selective and allow the rapid flux of potassium ions through their pore1. Several studies have implicated the H5 (P or SS1-SS2) segment2,3 as part of the pore in voltage-gated ion channels4–10. The proposal that H5 spans at least 80% of the electric potential drop across the K+ channel pore5,11 is based on altered internal tetraethylammonium sensitivity arising from mutations of H5 residues that are 100% conserved among K+ channels having differing sensitivity to… CONTINUE READING
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Selectivity Changes during Activation of Mutant Shaker Potassium Channels

The Journal of general physiology • 1997
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