Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.

@article{Sugimoto1984EvidenceTT,
  title={Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.},
  author={Yuji Sugimoto and Malcolm R Whitman and Lewis C. Cantley and Raymond Leo Erikson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 7},
  pages={2117-21}
}
The ability of purified Rous sarcoma virus transforming gene product, pp60v-src, to phosphorylate phosphatidylinositol and diacylglycerol was investigated. Phosphatidylinositol was phosphorylated to form both mono- and diphosphorylated derivatives. 1,2-Diacylglycerol was phosphorylated to form phosphatidic acid. These activities showed the same thermolability and the same sensitivity to inhibitors as shown by the casein kinase activity of pp60v-src. In addition, when serum-starved chicken… CONTINUE READING

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