Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.

@article{Delhommeau2007EvidenceTT,
  title={Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.},
  author={François Delhommeau and Sabrina Dupont and Carole Tonetti and Aline Mass{\'e} and Isabelle Godin and Jean-Pierre Le Cou{\'e}dic and Najet Debili and Patrick Saulnier and Nicole Casadevall and William Vainchenker and St{\'e}phane Giraudier},
  journal={Blood},
  year={2007},
  volume={109 1},
  pages={
          71-7
        }
}
The JAK2 V617F mutation has recently been described as an essential oncogenic event associated with polycythemia vera (PV), idiopathic myelofibrosis (IMF), and essential thrombocythemia. This mutation has been detected in all myeloid lineages but has not yet been detected in lymphoid cells. This raises the question whether this molecular event occurs in a true lymphomyeloid progenitor cell. In this work, we studied the presence of the mutation in peripheral blood cells and sorted B, T, and… CONTINUE READING

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