Evidence that the Density of Self Peptide-MHC Ligands Regulates T-Cell Receptor Signaling

Abstract

Noncognate or self peptide-MHC (pMHC) ligands productively interact with T-cell receptor (TCR) and are always in a large access over the cognate pMHC on the surface of antigen presenting cells. We assembled soluble cognate and noncognate pMHC class I (pMHC-I) ligands at designated ratios on various scaffolds into oligomers that mimic pMHC clustering and… (More)
DOI: 10.1371/journal.pone.0041466

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Cite this paper

@inproceedings{Anikeeva2012EvidenceTT, title={Evidence that the Density of Self Peptide-MHC Ligands Regulates T-Cell Receptor Signaling}, author={Nadia Anikeeva and Dimitry M Gakamsky and J\orgen Sch\oller and Yuri Sykulev}, booktitle={PloS one}, year={2012} }