Evidence that the 5-HT1A autoreceptor is an important pharmacological target for the modulation of cocaine behavioral stimulant effects

  title={Evidence that the 5-HT1A autoreceptor is an important pharmacological target for the modulation of cocaine behavioral stimulant effects},
  author={Robert J. Carey and Gail DePalma and Ernest N. Damianopoulos and Arielle B. Shanahan and Christian P. M{\"u}ller and Joseph P. Huston},
  journal={Brain Research},

Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats

Cocaine-induced hyperactivity and conditioned place preference, as well as intravenous cocaine self-administration were enhanced in SERT−/− rats, and data indicate that SERT/−-associated 5-HT1A receptor adaptations facilitate low-dose cocaine effects and attenuate high- dose cocaine effects in cocaine supersensitive animals.

5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking

An important role is suggested for 5-HT1A autoreceptors, and thus DRNNAc 5- HT neuronal activity, in the etiology and vulnerability to cocaine reward and addiction.

The interplay between brain 5-hydroxytryptamine levels and cocaine addiction

Overall, the data indicate that 5-HT plays a major role in the psychomotor stimulant, rewarding and discriminative stimulant effects of cocaine, but also affects the motivational and reinforcing effects of the drug.

Tolerance to the Behavioural and Neurochemical Effects of MDMA Following Repeated Exposure

MDMA produced dose-dependent hyperactivity and tolerance was produced by MDMA pretreatment and rats were tolerant to the effects of MDMA and m-CPP two weeks following MDMA Pretreatment.



The 5-HT1A receptor and behavioral stimulation in the rat: effects of 8-OHDPAT on spontaneous and cocaine-induced behavior

It is suggested that the facilitatory effect of 8-OHDPAT on cocaine-induced locomotor stimulation is mediated by inhibition of 5-HT1A somato-dendritic autoreceptors.

Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine

While the functional significance of 5-HT receptors has not been fully elucidated, data suggest that changes in serotonergic activity can modulate the effects of cocaine in both animals and humans under a variety of experimental conditions.

Postsynaptic 5-HT1A receptors mediate an increase in locomotor activity in the monoamine-depleted rat

The present data indicate that R-(+)-8-OHDPAT can increase motor activity in monoamine-depleted rats through postsynaptic 5- HT1A receptors and not necessarily through 5-HT1A autoreceptor-mediated alterations in5-HT synthesis and release.

Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone.

The i.v. administration of the 5-hydroxytryptamine (5-HT)1A antagonist spiperone did not alter the responsiveness to microiontophoretic applications of 5-HT and 8-OH-DPAT of pyramidal neurons in the CA3 region of the hippocampus, therefore indicating that spiper one does not act as a classical antagonist at these postsynaptic 5- HT1A receptors.