Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane.

@article{Henderson1974EvidenceTT,
  title={Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane.},
  author={Richard Henderson and Jennifer M. Ritchie and Gary R. Strichartz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1974},
  volume={71 10},
  pages={3936-40}
}
The effects of monovalent, divalent, and trivalent cations on the binding of tetrodotoxin and saxitoxin to intact nerves and to a preparation of solubilized nerve membranes have been examined. All eight divalent and trivalent cations tested, and the monovalent ions Li(+), Tl(+), and H(+) appear to compete reversibly with the toxins for their binding site. The ability of lithium to reduce toxin binding is paralleled by its ability to reduce tetrodotoxin-sensitive ion fluxes through the nerve… CONTINUE READING

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