Evidence that talin alternative splice variants from Ciona intestinalis have different roles in cell adhesion

@article{Singiser2006EvidenceTT,
  title={Evidence that talin alternative splice variants from Ciona intestinalis have different roles in cell adhesion},
  author={Richard H Singiser and Richard O. McCann},
  journal={BMC Cell Biology},
  year={2006},
  volume={7},
  pages={40 - 40}
}
Talins are large, modular cytoskeletal proteins found in animals and amoebozoans such as Dictyostelium discoideum. Since the identification of a second talin gene in vertebrates, it has become increasingly clear that vertebrate Talin1 and Talin2 have non-redundant roles as essential links between integrins and the actin cytoskeleton in distinct plasma membrane-associated adhesion complexes. The conserved C-terminal I/LWEQ module is important for talin function. This structural element mediates… CONTINUE READING

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