Evidence that stem cell factor is involved in the rebound thrombocytosis that follows 5-fluorouracil treatment.

@article{Hunt1992EvidenceTS,
  title={Evidence that stem cell factor is involved in the rebound thrombocytosis that follows 5-fluorouracil treatment.},
  author={Peter Hunt and Krisztina M. Zsebo and M M Hokom and A C Hornkohl and Nick R. C. Birkett and Javier del Castillo and Flavius Martin},
  journal={Blood},
  year={1992},
  volume={80 4},
  pages={904-11}
}
The mechanisms responsible for 5-fluorouracil (5FU)-induced rebound thrombocytosis are not completely understood. SI/SI(d) mice, which do not undergo rebound thrombocytosis in response to 5FU, provide a genetic approach to the study of this phenomenon. Recent reports by several groups that the SI locus encodes a protein known variably as stem cell factor (SCF), mast cell growth factor, or kit ligand, suggests the possibility that the lack of wild-type SCF in SI/SI(d) mice is responsible for… CONTINUE READING

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Zsebo KM: The role of recombinant stem cell factor in early B cell development: Synergistic interaction with IL

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