Evidence that soyasaponin Bb retards disease progression in a murine model of polycystic kidney disease.

@article{Philbrick2003EvidenceTS,
  title={Evidence that soyasaponin Bb retards disease progression in a murine model of polycystic kidney disease.},
  author={Diana J Philbrick and Dominique P. Bureau and Fergus W. J. Collins and Bruce John Holub},
  journal={Kidney international},
  year={2003},
  volume={63 4},
  pages={1230-9}
}
BACKGROUND We reported a lessened cyst growth in the pcy mouse model of polycystic kidney disease (PKD) when mice were fed a soy protein isolate (SPI)-based diet and hypothesized that the soyasaponins may be associated with this therapeutic effect. The effects of feeding a saponin-enriched alcohol extract (SEAE) from SPI, an isoflavone- and saponin-enriched soy supplement (Novasoy 400), or a 99.5% pure soyasaponin Bb powder on cyst growth are reported here. METHODS The therapeutic effects of… CONTINUE READING