Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain.

@article{Volkow2012EvidenceTS,
  title={Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain.},
  author={Nora D. Volkow and Dardo Tomasi and Gene-Jack Wang and Frank Telang and Joanna S. Fowler and Jean Logan and Helene Benveniste and Ron M Kim and Panayotis K. Thanos and Sergi Ferr{\'e}},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 19},
  pages={6711-7}
}
Dopamine D2 receptors are involved with wakefulness, but their role in the decreased alertness associated with sleep deprivation is unclear. We had shown that sleep deprivation reduced dopamine D2/D3 receptor availability (measured with PET and [(11)C]raclopride in controls) in striatum, but could not determine whether this reflected dopamine increases ([(11)C]raclopride competes with dopamine for D2/D3 receptor binding) or receptor downregulation. To clarify this, we compared the dopamine… CONTINUE READING
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