Evidence that selective collateral elimination during postnatal development results in a restriction in the distribution of locus coeruleus neurons which project to the spinal cord in rats.

Abstract

Experiments utilizing retrogradely transported fluorescent tracers in rats reveal that coeruleospinal cells are present throughout the locus coeruleus just after birth, but are confined to its ventral portion by the end of the fourth postnatal week. This change in distribution is not brought about by cell death, since neurons retrogradely labeled through… (More)

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