Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity.

@article{Coffman1987EvidenceTR,
  title={Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity.},
  author={Thomas M. Coffman and Daniel Carr and W E Yarger and Paul E. Klotman},
  journal={Transplantation},
  year={1987},
  volume={43 2},
  pages={282-5}
}
Previous reports suggest that cyclosporine (CsA) may have direct effects on arachidonic acid (AA) metabolism in several different tissues. However, the effects of CsA on renal eicosanoid production are unclear. Furthermore, the potential role of changes in renal prostaglandin and thromboxane metabolism in mediating CsA nephrotoxicity is not known. Therefore… CONTINUE READING