Evidence that regulatory protein MarA of Escherichia coli represses rob by steric hindrance.

@article{McMurry2010EvidenceTR,
  title={Evidence that regulatory protein MarA of Escherichia coli represses rob by steric hindrance.},
  author={Laura M. McMurry and S. Berville Levy},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 15},
  pages={
          3977-82
        }
}
The MarA protein of Escherichia coli can both activate and repress the initiation of transcription, depending on the position and orientation of its degenerate 20-bp binding site ("marbox") at the promoter. For all three known repressed genes, the marbox overlaps the promoter. It has been reported that MarA represses the rob promoter via an RNA polymerase (RNAP)-DNA-MarA ternary complex. Under similar conditions, we found a ternary complex for the repressed purA promoter also. These findings… CONTINUE READING

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MarA, SoxS and Rob of Escherichia coli - Global regulators of multidrug resistance, virulence and stress response.

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