Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms

@article{Roy2005EvidenceTP,
  title={Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms},
  author={Meenakshi Roy and Qiang Xu and Christopher Y Lee},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={5026 - 5033}
}
Alternative splicing is widespread in the human genome, and it appears that many genes display different splice forms in cancerous tissue than in normal human tissues. However, since cDNAs for many cancer-associated genes were originally cloned from tumor samples, it is important to ask whether this repertoire of cDNAs provides a complete or representative… CONTINUE READING