Evidence that protons act as neurotransmitters at vestibular hair cell-calyx afferent synapses.

@article{Highstein2014EvidenceTP,
  title={Evidence that protons act as neurotransmitters at vestibular hair cell-calyx afferent synapses.},
  author={Stephen M. Highstein and Gay R Holstein and Mary Anne Mann and Richard D. Rabbitt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 14},
  pages={5421-6}
}
Present data support the conclusion that protons serve as an important neurotransmitter to convey excitatory stimuli from inner ear type I vestibular hair cells to postsynaptic calyx nerve terminals. Time-resolved pH imaging revealed stimulus-evoked extrusion of protons from hair cells and a subsequent buildup of [H(+)] within the confined chalice-shaped synaptic cleft (ΔpH ∼ -0.2). Whole-cell voltage-clamp recordings revealed a concomitant nonquantal excitatory postsynaptic current in the… CONTINUE READING
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