Evidence that protein binding specifies sites of DNA demethylation.

  • C. L. Hsieh
  • Published 1999 in Molecular and cellular biology


It has been hypothesized that protein factors may protect CpG islands from methyltransferase during development and that demethylation may involve protein-DNA interactions at demethylated sites. However, direct evidence has been lacking. In this study, demethylation at the EBNA-1 binding sites of the Epstein-Barr virus latent replication origin, oriP, was… (More)


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