Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes

@article{Park2006EvidenceTP,
  title={Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes},
  author={Gyu Hwan Park and Jae Ryun Ryu and Chan Young Shin and Min Sik Choi and Byoung Hee Han and Won-Ki Kim and Hyoung‐Chun Kim and Kwang Ho Ko},
  journal={Neuroscience Research},
  year={2006},
  volume={54},
  pages={15-23}
}
Serine proteases such as thrombin and trypsin play a key role in the development and repair processes in the central nervous system. Molecular actions of serine proteases include multiple cellular events like activation of protease-activated receptors (PARs). PARs belong to a family of G protein-coupled receptors that can be stimulated through their proteolytic cleavage by ligands. PAR-2 has been implicated in neurodegenerative diseases including astrogliosis. Although recent studies have shown… Expand
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