Evidence that prolyl endopeptidase participates in the processing of brain angiotensin.

@article{Welches1991EvidenceTP,
  title={Evidence that prolyl endopeptidase participates in the processing of brain angiotensin.},
  author={W R Welches and Robson Santos and Mark C. Chappell and K. Bridget Brosnihan and Lewis Joel Greene and Carlos Maria Ferrario},
  journal={Journal of hypertension},
  year={1991},
  volume={9 7},
  pages={631-8}
}
In order to understand angiotensin metabolism in the canine brain, we determined the molecular forms of angiotensin peptides present in the hypothalamus of the dog and carried out measurements of the metabolism of 125I-angiotensin I in homogenates of that tissue. Angiotensin peptides were extracted from canine hypothalamic tissue and quantified by specific radioimmunoassays combined with high-performance liquid chromatography. The major angiotensin peptides detected were angiotensin-(2-7) (391… CONTINUE READING