Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87).

@article{Pavlicek2008EvidenceTP,
  title={Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87).},
  author={Jiri Pavlicek and Steven L. Coon and Surajit Ganguly and Joan L. Weller and Sergio A. Hassan and Dan L. Sackett and David C. Klein},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 21},
  pages={14552-8}
}
Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation of serotonin, the penultimate step in the synthesis of melatonin. Pineal AANAT activity increases at night in all vertebrates, resulting in increased melatonin production. This increases circulating levels of melatonin, thereby providing a hormonal signal of darkness. Kinetic and structural analysis of AANAT has determined that one element is floppy. This element, termed Loop 1, is one of three loops that comprise the… CONTINUE READING