Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease.

@article{ShibaFukushima2017EvidenceTP,
  title={Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease.},
  author={Kahori Shiba-Fukushima and Kei-ichi Ishikawa and Tsuyoshi Inoshita and Nana Izawa and Masashi Takanashi and Shigeto Sato and Osamu Onodera and Wado Akamatsu and Hideyuki Okano and Yuzuru Imai and Nobutaka Hattori},
  journal={Human molecular genetics},
  year={2017},
  volume={26 16},
  pages={3172-3185}
}
The ubiquitin (Ub) kinase PINK1 and the E3 Ub ligase Parkin, two gene products associated with young-onset Parkinson's disease (PD), participate in mitochondrial quality control. The phosphorylation of mitochondrial polyUb by PINK1, which is activated in a mitochondrial membrane potential (ΔΨm)-dependent manner, facilitates the mitochondrial translocation and concomitant enzymatic activation of Parkin, leading to the clearance of phospho-polyUb-tagged mitochondria via mitophagy. Thus, Ub… CONTINUE READING
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