Evidence that phospholipase delta1 is the effector in the Gh (transglutaminase II)-mediated signaling.


A new class of GTP-binding protein transglutaminase II (Gh) couples to a 69-kDa phospholipase C (PLC). An 8-amino acid region (Leu665-Lys672) of the alpha-subunit of Gh (Galphah) is involved in interaction and activation of PLC, an observation that has now been used to characterize the 69-kDa PLC further. A 20-amino acid peptide corresponding to Leu654… (More)


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