Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.

@article{Yamaguchi2002EvidenceTN,
  title={Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.},
  author={Yuki Yamaguchi and Naoto Inukai and Takashi Narita and Tadashi Wada and Hiroshi Handa},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 9},
  pages={2918-27}
}
Negative elongation factor (NELF) is a human transcription factor complex that cooperates with DRB sensitivity-inducing factor (DSIF)/hSpt4-hSpt5 to repress elongation by RNA polymerase II (RNAPII). NELF activity is associated with five polypeptides, including NELF-A, a candidate gene product for Wolf-Hirschhorn syndrome, and NELF-E, a putative RNA-binding protein with arginine-aspartic acid (RD) dipeptide repeats. Here we report several important findings regarding the DSIF/NELF-dependent… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
NELF activity is associated with five polypeptides , including NELF - A , a candidate gene product for Wolf - Hirschhorn syndrome , and NELF - E , a putative RNA - binding protein with arginine - aspartic acid ( RD ) dipeptide repeats .
NELF activity is associated with five polypeptides , including NELF - A , a candidate gene product for Wolf - Hirschhorn syndrome , and NELF - E , a putative RNA - binding protein with arginine - aspartic acid ( RD ) dipeptide repeats .
Negative elongation factor ( NELF ) is a human transcription factor complex that cooperates with DRB sensitivity - inducing factor ( DSIF)/hSpt4-hSpt5 to repress elongation by RNA polymerase II ( RNAPII ) .
All Topics