• DOI:10.1016/0014-2999(83)90198-X
Corpus ID: 98243591

Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a κ-opioid receptor

@article{Leander1983EvidenceTN,
  title={Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a κ-opioid receptor},
  author={J. Leander},
  journal={European Journal of Pharmacology},
  year={1983},
  volume={86},
  pages={467-470}
}

J. Leander

Published 1983

Medicine

European Journal of Pharmacology

Nalorphine, butorphanol and oxilorphan were compared in their ability to increase urinary output in the normally hydrated rat and to antagonize the increased urinary output produced by the full kappa-agonist, bremazocine. Nalorphine, butorphanol and oxilorphan increased 5-h cumulative urine output compared to controls, but the maximal effect was less than half the amount excreted after injection with 0.08 mg/kg of bremazocine. The effects of bremazocine were antagonized by nalorphine… CONTINUE READING

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