Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a κ-opioid receptor

@article{Leander1983EvidenceTN,
  title={Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a κ-opioid receptor},
  author={J. Leander},
  journal={European Journal of Pharmacology},
  year={1983},
  volume={86},
  pages={467-470}
}
  • J. Leander
  • Published 1983
  • Medicine
  • European Journal of Pharmacology
  • Nalorphine, butorphanol and oxilorphan were compared in their ability to increase urinary output in the normally hydrated rat and to antagonize the increased urinary output produced by the full kappa-agonist, bremazocine. Nalorphine, butorphanol and oxilorphan increased 5-h cumulative urine output compared to controls, but the maximal effect was less than half the amount excreted after injection with 0.08 mg/kg of bremazocine. The effects of bremazocine were antagonized by nalorphine… CONTINUE READING
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