Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae

@inproceedings{Kaya2015EvidenceTM,
  title={Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae},
  author={Alaattin Kaya and Alexei V. Lobanov and Vadim N. Gladyshev},
  booktitle={Aging cell},
  year={2015}
}
The concept that mutations cause aging phenotypes could not be directly tested previously due to inability to identify age-related mutations in somatic cells and determine their impact on organismal aging. Here, we subjected Saccharomyces cerevisiae to multiple rounds of replicative aging and assessed de novo mutations in daughters of mothers of different age. Mutations did increase with age, but their low numbers, < 1 per lifespan, excluded their causal role in aging. Structural genome changes… CONTINUE READING
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