Evidence that muscarinic receptors in islet cells are not coupled functionally to adenylate cyclase through the inhibitory guanine nucleotide binding protein (Ni).

Abstract

The effect of muscarinic agonist on adenylate cyclase was investigated in neonatal islet cells and in a clonal pituitary cell line (GH4C1) following labelling of the intracellular ATP pool with [2,8 3H]adenine. In islet cells carbamylcholine was without effect on basal or glucagon-stimulated adenylate cyclase activity, measured as 3H cyclic AMP production… (More)

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@article{Dunlop1988EvidenceTM, title={Evidence that muscarinic receptors in islet cells are not coupled functionally to adenylate cyclase through the inhibitory guanine nucleotide binding protein (Ni).}, author={Marjorie E. Dunlop and Marsha Shaw and Evdokia Dimitriadis and Volker Gurtler and John Dennis Wark and Richard G. Larkins}, journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme}, year={1988}, volume={20 3}, pages={150-3} }