Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist.

@article{Fernando1997EvidenceTM,
  title={Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist.},
  author={Susanthi R. Fernando and Roger G Pertwee},
  journal={British journal of pharmacology},
  year={1997},
  volume={121 8},
  pages={1716-20}
}
1. Methyl arachidonyl fluorophosphonate (MAFP) (1 microM) significantly attenuated the ability of WIN 55,212-2, CP 55,940, (-)-delta 9-tetrahydrocannabinol (THC), nabilone and (R)-(+)-arachidonoyl-1'-hydroxy-2'-propylamide (methanandamide) to inhibit electrically-evoked isometric contractions of the myenteric plexus-longitudinal muscle preparation of guinea-pig small intestine. 2. The sizes of the maximal responses to WIN 55,212-2 and CP 55,940 decreased significantly in the presence of 1… CONTINUE READING
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