Evidence that mast cell degranulation, histamine and tumour necrosis factor alpha release occur in LPS-induced plasma leakage in rat skin.

@article{Iuvone1999EvidenceTM,
  title={Evidence that mast cell degranulation, histamine and tumour necrosis factor alpha release occur in LPS-induced plasma leakage in rat skin.},
  author={Teresa Iuvone and R V Den Bossche and Fulvio D'Acquisto and Rosa Carnuccio and Arnold G. Herman},
  journal={British journal of pharmacology},
  year={1999},
  volume={128 3},
  pages={700-4}
}
1. In the present study we investigated the role of mast cells during inflammation in rat skin. As the release of several pro-inflammatory mediators, such as histamine and tumour necrosis factor alpha (TNFalpha), occurs following mast cell activation we studied whether mast cell degranulation and the release of both histamine (H) and TNFalpha occurred in a model of lipopolysaccharide (LPS)-induced plasma leakage in rat skin. 2. Plasma leakage in the rat skin was measured over a period of 2 h as… CONTINUE READING