Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling.

@article{Dula2010EvidenceTL,
  title={Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling.},
  author={Stacey B. Dula and Mladen Jecmenica and Runpei Wu and Pooya Jahanshahi and Gretchen M Verrilli and Jeffrey D Carter and K L Brayman and Craig S Nunemaker},
  journal={Cell calcium},
  year={2010},
  volume={48 2-3},
  pages={133-42}
}
In obesity and the early stages of type 2 diabetes (T2D), proinflammatory cytokines are mildly elevated in the systemic circulation. This low-grade systemic inflammation exposes pancreatic islets to these circulating cytokines at much lower levels than seen within the islet during insulitis. These low-dose effects have not been well described. We examined mouse islets treated overnight with a low-dose cytokine combination commonly associated with inflammation (TNF-alpha, IL-1 beta, and IFN… CONTINUE READING

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In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
In obesity and the early stages of type 2 diabetes ( T2D ) , proinflammatory cytokines are mildly elevated in the systemic circulation .
Our data suggest that chronic low - grade inflammation produces circulating cytokine levels that are sufficient to induce beta - cell dysfunction and may play a contributing role in beta - cell failure in early T2D.
Our data suggest that chronic low - grade inflammation produces circulating cytokine levels that are sufficient to induce beta - cell dysfunction and may play a contributing role in beta - cell failure in early T2D.
Our data suggest that chronic low - grade inflammation produces circulating cytokine levels that are sufficient to induce beta - cell dysfunction and may play a contributing role in beta - cell failure in early T2D.
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