Evidence that loss of chromosome 18q is associated with tumor progression.

@article{Frank1997EvidenceTL,
  title={Evidence that loss of chromosome 18q is associated with tumor progression.},
  author={Christopher J. Frank and Kenneth D. McClatchey and Kenneth Owen Devaney and Thomas E. Carey},
  journal={Cancer research},
  year={1997},
  volume={57 5},
  pages={824-7}
}
Four sets of cell lines (UM-SCC-14A, -14B, and -14C; UM-SCC-17A and -17B; UM-SCC-81A and -81B; and UM-SCC-83A and -83B), established from primary and metastatic or locally recurrent tumors from four patients with squamous cell carcinoma of the head and neck, were examined for loss of heterozygosity (LOH) on chromosome 18q. Metastatic or recurrent cell lines from all four exhibited 18q LOH. UM-SCC-14A, -14B, and -14C, which were derived from locally recurrent (14A and 14B) and metastatic (14C… CONTINUE READING
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