Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus.

@article{Nolan2003EvidenceTL,
  title={Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus.},
  author={Yvonne M Nolan and Emily Vereker and Aileen M Lynch and Marina A. Lynch},
  journal={Experimental neurology},
  year={2003},
  volume={184 2},
  pages={794-804}
}
Lipopolysaccharide (LPS) administration stimulates immune activation, inflammation and deterioration in cell function. Neuronal tissue in cortex and hippocampus are particularly susceptible. In this study, we report that LPS induces cell death as measured by caspase-3 activation and DNA fragmentation and that this is coupled with stimulation of the mitogen-activated protein kinase, p38. We provide evidence of co-localization of activated p38 and caspase-3 in cells prepared from cortical and… CONTINUE READING

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