Evidence that late-generated granule cells do not simply replace earlier formed neurons in the rat dentate gyrus

@article{Crespo1986EvidenceTL,
  title={Evidence that late-generated granule cells do not simply replace earlier formed neurons in the rat dentate gyrus},
  author={D{\'a}maso Crespo and Brent B. Stanfield and W. Cowan},
  journal={Experimental Brain Research},
  year={1986},
  volume={62},
  pages={541-548}
}
Ten-day-old Sprague-Dawley rats were injected intraperitoneally with 3H-thymidine (3HTdR) and allowed to survive until postnatal day (P) 40, P120, P200, P300 or P450. Following the preparation of the tissue for autoradiography, the location of the labeled neurons within the granule cell layer of the dentate gyrus was determined at two different septo-temporal levels. At P40 the labeled cells in the suprapyramidal blade of the dentate gyrus were found only in the deep part of the granule cell… CONTINUE READING