Evidence that hypophagia induced bymCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors

@article{Kennett2006EvidenceTH,
  title={Evidence that hypophagia induced bymCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors},
  author={Guy A. Kennett and Gerald Curzon},
  journal={Psychopharmacology},
  year={2006},
  volume={96},
  pages={93-100}
}
Male Sprague-Dawley rats deprived of food for 18 h were injected with the 5-HT agonists RU 24969, 1-(3-chlorophenyl)piperazine (mCPP) or 1-[3-(trifluoromethyl)phenyl)]piperazine (TFMPP) and 20 min later presented with their normal diet. Food intake was determined 1, 2 and 4 h later. All three drugs reduced intake over 1 and 2 h. Three out of four drugs with high affinity for 5-HT1C receptors (metergoline, mianserin, and mesulergine but not cyproheptadine) opposed hypophagia caused bymCPP… Expand
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TLDR
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Infusion of the 5-hydroxytryptamine agonists RU24969 and TFMPP into the paraventricular nucleus of the hypothalamus causes hypophagia
The 5-HT1B agonist RU24969 when given either systemically (1 mg/kg SC) or by infusion (0.5, 1.0, 2.0 μg) into the region of the paraventricular nucleus of the hypothalamus caused dose-dependentExpand
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WAY100635 blocks the hypophagia induced by 8-OH-DPAT in the hypothalamic nuclei
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Evidence that 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced hyperthermia in rats is mediated by stimulation of 5-HT2A receptors
TLDR
It is suggested that DOI-induced hyperthermia in rats is mediated by stimulation of 5-HT2A receptors, and daily administration of DOI for 17 days did not produce either tolerance to its hyperthermic effect or modifym-CPP-induced hypothermia in Rats. Expand
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TLDR
It is suggested that FR260010 is a novel, potent, orally active and brain penetrable antagonist of 5-HT(2C) receptor, and may have therapeutic potential for treatment of anxiety, with more desirable profiles than benzodiazepines or 5-hydroxytryptamine(1A) (5-HT (1A)) receptor agonists. Expand
RU 24969-induced locomotion in rats is mediated by 5-HT1A receptors
  • H. Kalkman
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
TLDR
The locomotor response to RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl) 1H-indole; 10 mg/kg, s.c.), a preferential 5-HT1B receptor agonist, was investigated in the rat and results suggest that RU 249 69-induced hyperlocomotion in the rats is mediated by 5- HT1A receptors. Expand
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