Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors

@article{Vickers2001EvidenceTH,
  title={Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors},
  author={Steven P. Vickers and Colin T. Dourish and Guy A. Kennett},
  journal={Neuropharmacology},
  year={2001},
  volume={41},
  pages={200-209}
}

Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice

The evidence suggests that an adaptive change in5-HT2C receptor function occurs in 5-HT1B receptor KO mice and contributes to their reduced response to d-fenfluramine.

3,4-N-Methlenedioxymethamphetamine-Induced Hypophagia is Maintained in 5-HT1B Receptor Knockout Mice, but Suppressed by the 5-HT2C Receptor Antagonist RS102221

These findings provide the first evidence that the in activation of 5-HT2C receptors may reduce hypophagia and motor response to MDMA, while a genetic deficit or pharmacological inactivation of5-HT1B receptors was insufficient to alter the feeding response to ecstasy.

Effects of fenfluramine on free-operant timing behaviour: evidence for involvement of 5-HT2A receptors

The results suggest that fenfluramine affects temporal differentiation via the release of endogenous 5-HT which acts mainly on postsynaptic 5- HT2A receptors.

Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.

It is suggested that fluvoxamine and inactivation of 5-HT2C receptors exert feeding suppression through activation of5-HT1B receptors, and that 4C receptors up-regulates hypothalamic POMC and CART gene expression and down-regulate hypothalamic orexin gene expression in mice.

(+)-Fenfluramine and Its Major Metabolite, (+)-Norfenfluramine, Are Potent Substrates for Norepinephrine Transporters

Administration of fenfluramines can increase synaptic levels of 5-HT, NE, and DA in the cortex, and (+)-norfenfluramine likely contributes to these effects.

Deconstructing Antiobesity Compound Action: Requirement of Serotonin 5-HT2B Receptors for Dexfenfluramine Anorectic Effects

Activation of presynaptic 5-HT2B receptors is a limiting step in the serotonin transporter dependant-releasing effect of dexfenfluramine, whereas other serotonin receptors act downstream with respect to feeding behavior.
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