Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors

  title={Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors},
  author={Steven P. Vickers and Colin T. Dourish and Guy A. Kennett},

Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice

The evidence suggests that an adaptive change in5-HT2C receptor function occurs in 5-HT1B receptor KO mice and contributes to their reduced response to d-fenfluramine.

3,4-N-Methlenedioxymethamphetamine-Induced Hypophagia is Maintained in 5-HT1B Receptor Knockout Mice, but Suppressed by the 5-HT2C Receptor Antagonist RS102221

These findings provide the first evidence that the in activation of 5-HT2C receptors may reduce hypophagia and motor response to MDMA, while a genetic deficit or pharmacological inactivation of5-HT1B receptors was insufficient to alter the feeding response to ecstasy.

Effects of fenfluramine on free-operant timing behaviour: evidence for involvement of 5-HT2A receptors

The results suggest that fenfluramine affects temporal differentiation via the release of endogenous 5-HT which acts mainly on postsynaptic 5- HT2A receptors.

Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.

It is suggested that fluvoxamine and inactivation of 5-HT2C receptors exert feeding suppression through activation of5-HT1B receptors, and that 4C receptors up-regulates hypothalamic POMC and CART gene expression and down-regulate hypothalamic orexin gene expression in mice.

(+)-Fenfluramine and Its Major Metabolite, (+)-Norfenfluramine, Are Potent Substrates for Norepinephrine Transporters

Administration of fenfluramines can increase synaptic levels of 5-HT, NE, and DA in the cortex, and (+)-norfenfluramine likely contributes to these effects.

Deconstructing Antiobesity Compound Action: Requirement of Serotonin 5-HT2B Receptors for Dexfenfluramine Anorectic Effects

Activation of presynaptic 5-HT2B receptors is a limiting step in the serotonin transporter dependant-releasing effect of dexfenfluramine, whereas other serotonin receptors act downstream with respect to feeding behavior.



Reduced satiating effect of d-fenfluramine in serotonin 5-HT2C receptor mutant mice

A role for the 5-HT2C receptor in mediating d-fenfluramine-induced satiety is demonstrated and is demonstrated to be a potent inhibitor of the re-uptake of5-HT into nerve terminals and a facilitator of behavioural satiety in mutant mice.

Absence of Fenfluramine-Induced Anorexia and Reduced c-fos Induction in the Hypothalamus and Central Amygdaloid Complex of Serotonin 1B Receptor Knock-Out Mice

It is demonstrated that stimulation of 5-HT1B receptors is required for fenfluramine-induced anorexia and a role for the PVN, CeA, and BNST in mediating this effect is suggested.

Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.

Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats

5‐HT1 and 5‐HT2 receptor subtypes do not play an important role in the hypophagic effect of sibutramine, at least in the first 2 h after injection, and the results suggest that, with the possible exception of a partial involvement of 5‐ HT2B/2C receptors in sibUTramine's hypophagia in food‐deprived rats.

(1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists.

It is demonstrated that 5-HT2A receptors mediate HTW in rats and that both D1 and D2 receptors as well as (postsynaptic) 5- HT1A receptors play a role in their expression.