Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

@article{Ikuta1992EvidenceTH,
  title={Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.},
  author={Koichi Ikuta and Irving L Weissman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 4},
  pages={1502-6}
}
The interaction of the mouse c-kit receptor, designated Kit receptor, and steel factor promotes the proliferation and differentiation of hematopoietic progenitor cells. Monoclonal antibodies against the extracellular portion of the mouse Kit receptor were established. Five percent to 10% of total bone marrow cells expressed the Kit receptor, and half of them lack the expression of lineage markers. The Kit receptor was expressed on 70-80% of Thy-1.1lo Lin-Sca-1+ cells, which express Thy-1.1… CONTINUE READING
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