Evidence that growth factors IGF-I, IGF-II and EGF can stimulate nuclear maturation of porcine oocytes via intracellular protein kinase A.

@article{Sirotkin2000EvidenceTG,
  title={Evidence that growth factors IGF-I, IGF-II and EGF can stimulate nuclear maturation of porcine oocytes via intracellular protein kinase A.},
  author={A V Sirotkin and Janka Dukesov{\'a} and Alexander V Makarevich and Alojz K{\'u}bek and Jozef Bulla},
  journal={Reproduction, nutrition, development},
  year={2000},
  volume={40 6},
  pages={559-69}
}
The aim of our in vitro experiments was to study the role of growth factors and protein kinase A (PKA)-dependent intracellular mechanisms in the control of nuclear maturation of porcine oocytes. Oocytes were cultured with or without growth factors (IGF-I, IGF-II, EGF; 10 ng x mL(-1) medium) and inhibitors of PKA (Rp-cAMPS or KT5720; 100 ng x mL(-1)). Stages… CONTINUE READING