Evidence that glutamine modulates respiratory burst in stressed rat polymorphonuclear cells through its metabolism into arginine.

@article{Moinard2002EvidenceTG,
  title={Evidence that glutamine modulates respiratory burst in stressed rat polymorphonuclear cells through its metabolism into arginine.},
  author={Christophe Moinard and Florence Caldefie-Ch{\'e}zet and St{\'e}phane Walrand and Marie-Paule Vasson and Luc A Cynober},
  journal={The British journal of nutrition},
  year={2002},
  volume={88 6},
  pages={689-95}
}
Glutamine (GLN) and arginine (ARG) are recognized for their ability to modulate immune cell function. However, the metabolic pathways involved in their action remain unclear. It was recently shown that GLN- or ARG-enriched diets increased radical oxygen species (ROS) production by neutrophils from stressed rats. Since these two amino acids have a tied metabolism, we hypothesized that conversion between GLN and ARG (and its active metabolites NO* and polyamines) might be involved. To test this… CONTINUE READING
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